脑缺血(cerebral ischemia,CI)具有高发病率、高致畸率,是全球第二大致死疾病.中药(traditional Chinese medicine,TCM)益气活血方......

Ischemic and traumatic insults to the central nervous system account for most serious acute and fatal brain injuries and......

Stroke is considered a leading cause of mortality and neurological disability,which puts a huge burden on individuals an......

Electroacupuncture (EA) has been shown to reduce blood lipid level and improve cerebral ischemia in rats with hyperlipem......

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Leukemia inhibitory factor (LIF) contributes to the neuroprotection by neural stem cells (NSCs) after ischemic stroke.Ou......

Objective To investigate the diagnostic efficacy of magnetic resonance diffusion-weighted imaging ( DWI ) on acute middl......

MicroRNA-99a(miR-99a) has been reported to function as a tumor suppressor through regulating cell cycle and apoptosis.Bu......

Objective The formation of glial scar impedes the neurogenesis and neural functional recovery following cerebral ischemi......

Preconditioning means that a previous minor insult prepares the body to better withstand a subsequent larger insult.High......

Background and Purpose We aimed to investigate whether NADPH oxidase,a major ROS-producing enzyme,was involved in the an......

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Objective: Electro-acupuncture(EA)is a novel therapy based on combining traditional acupuncture with modern electrothera......

Sphingosine kinases(Sphks) are the rate-limiting kinases in the generation ofsphingosine-1-phosphate,which is a well-est......

Background:Oxidative stress and inflammatory damage play an important role in cerebral ischemic pathogenesis and may rep......

Aim: It was generally believed that excessive potassium efflux was one of the primary causes of neuronal injury after ce......

Aim: The tryptophan metabolic enzyme systems of indoleamine 2,3-dioxygenase (IDO) and tryptophanyl-tRNA synthetase (TrpR......

The lipid-sensitive mechano-gated TREK-1 has been shown to be predominantly expressed in the CNS.However, its regional a......

Objective For investigating whether overexpression of PDZ1 domain of PSD-95 can inhibit apoptosis in neurons induced by ......

Objective Decreased blood flow to the brain causes stroke and damage to neuronal networks.Neuronal damage occurs not onl......

Background Various mammalian species,including human being,have neural stem cells (NSCs) in central nervous system all t......

Introduction:Transient receptor potential vanilloid 4 (TRPV4) is widely expressed in the central nervous system and can ......

Aim: To investigate the neuro-protective effects and underlying mechanisms of uric acid on rat cerebral ischemia/reperfu......

Aim: To investigate the effects of MNG extracted from Cornus officinalis on neurogenesis and Wnt signaling after focal c......

Aim: In this study we investigated the neuroprotective effect of oxysophoridine (OSR) on ischemia and ischemia-like insu......

Aim: To study the effect of Garidi-13 on neurological score, pathological changes,serum levels of NSE, TNF-α, IL-1β, I......

Objective Several lines of evidences indicated that autophagy was involved in ischemic brain injury.Ischemia/reperfusion......

Objective Angiogenesis and inflammation are induced immediately after cerebral ischemia,and play a pivotal role in the s......

Neuroserpin (NSP) is regarded for its neuroprotection in cerebral ischemic animal models and patients;our current study ......

Ethnopharmacological relevance Hemorrhagic transformation is a frequent asymptomatic event that occurs after acute ische......

Aim: Blood brain barrier (BBB) dysfunction is a common facet of cerebral ischemia, and the alteration of drug transporte......

Objective Cerebral ischemia may contribute to the pathogenesis of Alzheimers disease (AD), however, the neuropathologica......

Objective Reduction in neuronal activity in remote brain regions after stroke is likely caused by a disruption of affere......

Acupuncture has been widely used to treat stroke in China.However,the possible mechanisms underlying are still unclear.I......

Objective To investigate the neuroprotective actions of pioliotazone (Piog) and the effects of Piog-mediated PPART activ......

Objective Using laser-Doppler flowmetry (LDF),the influence of tetramethylpyrazine (TMP) on regional cerebral blood flow......

Aim: To investigate the effect of compatibility of Astragalosides (AST) with Panax Notoginseng Saponins (PNS) on the exp......

Objective: To investigate the protective effect of the new compound XJ-1 which was derived from Chinese herb Dragon’s b......

Cysteinyl leukotrienes (CysLTs) induce inflammatory responses by activating their receptors,CysLT1R and CysLT2R.We have ......

In this study, we investigated the neuroprotective effects of paclitaxel in transient cerebral ischemia and the possible......

Objective Glycer-aldehyde-3-phosphate dehydrogenase (GAPDH), a glycolytic enzyme, has long been considered a housekeepin......

Prompt reperfusion after cerebral ischemia is critical for neuronal survival.Any strategies extend the limited reperfusi......

The function of aquaporin 9(AQP9)and its corresponding mechanism in chronic cerebral ischemia are not well defined.We re......

Long-term metformin treatment reduces the risk of stroke.However,the effective administration pattern and indications of......

目的：microglial cells are the innate immune effector cells of the brain,which are the key to the post-traumatic injury an......

Module-based methods have made much progress in deconstructing biological networks.However, it is a great challenge to q......

This paper aimed to explore the protective effects of picroside Ⅱ against the neuronal apoptosis and changes in morphol......

Currently effective neuroprotective agents are still not availablefor cerebral ischemia, probably due to its complicated......

Cerebral ischemia and reperfusion is one of the leading causes for death and severe disabilities in the world and often ......